Filler dissolving

The enzyme does most of its work within about 30 minutes in the tissue, and particulate fillers can visibly break down within 1 to 2 hours. Heavily cross-linked monophasic gels can take up to 24 hours and often need a second dose. Swelling from the injection hides the change, so the honest read is at 48 hours, with the settled result at about 2 weeks.

No. It only degrades hyaluronic acid — the Juvéderm, Restylane and Belotero families and their equivalents. Poly-L-lactic acid, calcium hydroxylapatite, polymethylmethacrylate and silicone are not reversible by enzyme and need entirely different management, which is why we want to know what was injected before we agree to treat.

For the first 1 to 2 weeks the area can look flatter, thinner and more lined, because the enzyme breaks down the hyaluronic acid your own skin makes as well as the filler. Skin hyaluronan turns over rapidly and this recovers. What is left afterwards is usually your pre-filler baseline rather than new damage — and dosing in small increments, instead of one large dose, limits how far it goes.

Not for this. Hyaluronidase products such as Hylenex are licensed as adjuvants to increase the dispersion and absorption of other injected drugs and fluids, and for subcutaneous urography. Dissolving dermal filler is off-label in the US and an unlicensed use of a prescription-only medicine in the UK — legitimate, standard practice everywhere, and something we put in the consent rather than leave unsaid.

2 weeks, as a minimum. That interval lets residual enzyme activity end, your own tissue hyaluronic acid regenerate, and the swelling settle so the true baseline is visible before anything is rebuilt. Injecting sooner risks the new filler being partly degraded and, more importantly, misjudging how much volume is actually needed.

Yes — it is the first-line treatment for filler-induced vascular occlusion, where filler blocks an artery and threatens skin necrosis or, around the eye, vision. High-dose hyaluronidase is flooded across the affected vascular territory immediately and repeated until perfusion returns. Any clinic injecting hyaluronic acid filler should hold hyaluronidase on site, and that is a fair question to ask before anyone injects you.

€150 to €500 per session with us, depending on how many areas are involved and how heavily cross-linked the filler is — consultation and assessment of what was originally injected, the enzyme, the injection and one review visit included. A single lip or one tear trough sits at the lower end. We should say plainly that no society survey or official source publishes hyaluronidase pricing for Turkey, so this is our editorial figure rather than a surveyed one.

Anyone with a bee or wasp venom allergy or a previous reaction to hyaluronidase — venom sensitisation is the main identified risk factor, and elective treatment waits for an allergist's assessment first. The enzyme is also withheld over actively infected or acutely inflamed skin unless a biofilm is being managed under antimicrobial cover, because it can spread a local infection. It does nothing at all for poly-L-lactic acid, calcium hydroxylapatite, polymethylmethacrylate or silicone. And it is not given electively in pregnancy or while breastfeeding, since there is no safety data to give it on. None of that applies to a suspected vascular occlusion, which is treated regardless.

Within minutes to hours: hives or itching spreading beyond the injection sites, swelling of the lips, tongue or throat, wheeze, or feeling faint. That is hypersensitivity and it needs treating immediately, not at the follow-up. In the days after: spreading redness, warmth, increasing pain, fever, or a new tender lump, which point to infection or an inflammatory nodule. Swelling, bruising and itching confined to the injection points are expected and peak in the first 24 to 72 hours.

Often it does not. Hyaluronic acid fillers are marketed with durations of 6 to 18 months, but MRI studies have found product still present in the face years after injection, and migrated lip and tear-trough filler is the most reported version of this. Those duration figures describe how long the aesthetic effect lasts, not how long the gel stays in the tissue — which is why waiting is a reasonable plan for a mild overfill and an unreliable one for filler that has moved.

Not reliably. Hyaluronidase diffuses through tissue and cannot tell your filler from the hyaluronic acid your own skin makes, so it will not stay confined to the portion you dislike. Dosing in small increments and reading the result at 48 hours limits how far it travels, but the honest framing is closer to all-or-nothing: clear the area, wait 2 weeks for your own baseline to return, then rebuild from there.

€150 to €500 with us, confirmed after a consultation rather than quoted blind. For comparison it is typically £150 – £400 per session in the United Kingdom, $300 – $800 per session in the United States and €150 – €400 per session in Western Europe. Per session, and the figure depends on how much filler is being dissolved. Old or heavily layered filler often takes more than one appointment.